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 Formulary Chapter 3: Respiratory system - Full Chapter
Notes:

Please contact EKHUFT Medicines Information ext. 7236001 or 01233 616001 with any queries.

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03.01.03  Expand sub section  Theophylline
 note 
STOPP v2 recommendation Theophylline inappropriate to use in patients aged 65 years and older as monotherapy for COPD (safer, more effective alternative; risk of adverse effects due to narrow therapeutic index).
Aminophylline (Phyllocontin Continus)
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Formulary
Green
Tablets






STOPP v2 recommendation Theophylline inappropriate to use in patients aged 65 years and older as monotherapy for COPD (aminophylline is metabolised to theophylline, safer, more effective alternative; risk of adverse effects due to narrow therapeutic index).
 
   
Aminophylline IV
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Formulary
Red
Injection
WarningIntravenous loading can be dangerous as requires complex calculation and patient may have been on aminophylline/theophylline orally without this being realised. See the Trust Guidelines for Adults. Dosing instructions in BNF are clear. ECG monitoring. 
Link  UKMI Q&A: Conversion of IV aminophylline dose to oral aminophylline or theophylline
   
Theophylline (Slo-Phyllin)
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Green
Capsules MR
  • Paediatrics
  • Due to differences in bioavailability of Theophylline, once stabilised, the patient should be maintained on the same brand.
  • Plasma-theophylline concentration for optimum response 1020 mg/litre (55110 micromol/litre); narrow margin between therapeutic and toxic dose





    STOPP v2 recommendation Theophylline inappropriate to use in patients aged 65 years and older as monotherapy for COPD (safer, more effective alternative; risk of adverse effects due to narrow therapeutic index).


     
  •    
    Theophylline (Uniphyllin Continus)
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    Formulary
    Green
    Tablets MR
  • Plasma-"theophylline" concentration for optimum response 1020 mg/litre (55110 micromol/litre); narrow margin between therapeutic and toxic dose





    STOPP v2 recommendation Theophylline inappropriate to use in patients aged 65 years and older as monotherapy for COPD (safer, more effective alternative; risk of adverse effects due to narrow therapeutic index).
     
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    Key
    note Notes
    Section Title Section Title (top level)
    Section Title Section Title (sub level)
    First Choice Item First Choice item
    Non Formulary Item Non Formulary section
    Restricted Drug
    Restricted Drug
    Unlicensed Drug
    Unlicensed
    Track Changes
    Display tracking information
    click to search medicines.org.uk
    Link to adult BNF
    click to search medicines.org.uk
    Link to children's BNF
    click to search medicines.org.uk
    Link to SPCs
    Cytotoxic Drug
    Cytotoxic Drug
    CD
    Controlled Drug
    High Cost Medicine
    High Cost Medicine
    Cancer Drugs Fund
    Cancer Drugs Fund
    NHSE
    NHS England
    Homecare
    Homecare
    CCG
    CCG

    Traffic Light Status Information

    Status Description

    Amber

    Requires to be initiated by specialist for repeat GP Prescribing (Purple as per Eclipse East Kent Primary Care Formulary, may be top sliced) If a downloadable EKPG Prescribing Information Sheet exists in the formulary entry for the drug, it, or an URL (shortcut to webpage/document) should be sent to the GP. See also "Hints in how to incorporate documents for medicines information into clinical communications to GPs".  

    Amber 1

    Shared Care (Orange as per Eclipse East Kent Primary Care Formulary). See the Principles of Shared Care Agreements and Shared Care Agreements: Assessment against agreed Principles of Shared Care documents. If a downloadable template document exists in the formulary entry for this drug, it should be sent to the GP (and patient) once patient specific details are incorporated. See "Hints in how to incorporate shared care documents for medicines into clinical communications to GPs".  

    Amber 2

    Shared Care and topsliced (Orange as per Eclipse East Kent Primary Care Formulary) See the Principles of Shared Care Agreements and Shared Care Agreements: Assessment against agreed Principles of Shared Care documents. If a downloadable template document exists in the formulary entry for this drug, it should be sent to the GP (and patient) once patient specific details are incorporated. See "Hints in how to incorporate shared care documents for medicines into clinical communications to GPs".  

    Black

    A decision has been made by either or both the local or national NHS not to routinely commission this preparation for its licensed indications  

    Blue

    No comment on drug in East Kent Primary Care Formulary (Blue as per Eclipse East Kent Primary Care Formulary)  

    Brown

    Exceptional Use Only (Brown as per Eclipse East Kent Primary Care Formulary)   

    Green

    On East Kent Primary Care Formulary (Pink or Green as per Eclipse East Kent Primary Care Formulary)  

    Grey

    Not assessed/Not recommended (As per Eclipse East Kent Primary Care Formulary)  

    Red

    Hospital Only (As per Eclipse East Kent Primary Care Formulary)  

    RedRed

    Known to be commissioned for local NHS patients but only available to them from another provider than EKHUFT  

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