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 Formulary Chapter 5: Infections - Full Chapter
Notes:

See
NHS
MicroGuide Icon on Trust desktops EKHUFT Antimicrobial Guidelines are in Microguide on Trust desktop PCs and as App www

Please refer to the EKHUFT antimicrobial guidelines via the link above for detailed information.

Updates of this chapter are ongoing. Please contact the antimicrobial team with any queries.
See Key messages for hospital prescribers from European Antibiotic Awareness and be aware Dutch hospital antimicrobial use is about one third less than UK

All antimicrobials should be prescribed according to the trust antimicrobial policy or on the advice of a microbiologist. Restricted antimicrobials should be prescribed for the use or department specified unless authorised by a microbiologist.

Please Note some non formulary items may be prescribed in exceptional circumstances under the Microbiology Team direction

 

 Details...
05.03.01  Expand sub section  HIV infection
 note 

EKHUFT is NOT a provider Trust for HIV Treatment

Contact GUM Consultant / Specialist HIV Nurse

NHS Antiretroviral drugs listed in the British National Formulary (BNF) chapter 05.03.01 are commissioned direct by NHS England in line with national policy.
Star All products in this section are high cost drugs reimbursed separately from NHS England tariff (PBR excluded)

05.03.01  Expand sub section  Nucleoside reverse transcriptase inhibitors
 note 
Star All products in this section are high cost drugs reimbursed separately from NHS England tariff (PBR excluded)
Tenofovir Disproxil (Viread®)
View adult BNF View SPC online View childrens BNF
Restricted Drug Restricted Tablets
  • Gastroenterology

  • In HIV indication: Non formulary

    HIV in combination with other anti-retroviral drugs - use according to BHIVA Guidelines. Continue in context suitable for shared care between specialist and secondary care via network model. Commissioned by NHS England Area Team.

    Critical medication: Omission of this medication in some of its indications can lead to serious patient harm of death. Please see continuity of critical medicines guidelines and procedure how to obtain medicines out of hours.
    MicroGuide Icon on Trust desktops link to microguide  
  • Link  NICE TA173: Hepatitis B - tenofovir disoproxil fumarate
       
    05.03.01  Expand sub section  Protease inhibitors
    05.03.01  Expand sub section  Non-nucleoside reverse transcriptase inhibitors
    05.03.01  Expand sub section  Other antiretrovirals to top
    05.03.01  Expand sub section  Pharmacokinetic enhancers of antiretrovirals
     ....
     Non Formulary Items
    Abacavir  (Ziagen®)

    View adult BNF View SPC online View childrens BNF
    Non Formulary
    RedRed
    HIV in combination with other anti-retroviral drugs - use according to BHIVA Guidelines. Continue in context suitable for shared care between specialist and secondary care via network model. Commissioned by NHS England Area Team.

    Critical medication: Omission of this medication in some of its indications can lead to serious patient harm of death. Please see continuity of critical medicines guidelines and procedure how to obtain medicines out of hours.



     
    Abacavir and Lamivudine  (Kivexa®)

    View adult BNF View SPC online View childrens BNF
    Non Formulary
    RedRed
    HIV in combination with other anti-retroviral drugs - use according to BHIVA Guidelines. Continue in context suitable for shared care between specialist and secondary care via network model. Commissioned by NHS England Area Team.

    Critical medication: Omission of this medication in some of its indications can lead to serious patient harm of death. Please see continuity of critical medicines guidelines and procedure how to obtain medicines out of hours.
     
    Abacavir and Lamivudine and Zidovudine  (Trizivir®)

    View adult BNF View SPC online View childrens BNF
    Non Formulary
    RedRed
    HIV in combination with other anti-retroviral drugs - use according to BHIVA Guidelines. Continue in context suitable for shared care between specialist and secondary care via network model. Commissioned by NHS England Area Team.

    Critical medication: Omission of this medication in some of its indications can lead to serious patient harm of death. Please see continuity of critical medicines guidelines and procedure how to obtain medicines out of hours.
     
    Didanosine  (Videx®)

    View adult BNF View SPC online View childrens BNF
    Non Formulary
    RedRed
    HIV in combination with other anti-retroviral drugs - use according to BHIVA Guidelines. Continue in context suitable for shared care between specialist and secondary care via network model. Commissioned by NHS England Area Team.

    Critical medication: Omission of this medication in some of its indications can lead to serious patient harm of death. Please see continuity of critical medicines guidelines and procedure how to obtain medicines out of hours.
     
    Emtricitabine  (Emtriva®)

    View adult BNF View SPC online View childrens BNF
    Non Formulary
    RedRed
    HIV in combination with other anti-retroviral drugs - use according to BHIVA Guidelines. Continue in context suitable for shared care between specialist and secondary care via network model. Commissioned by NHS England Area Team.

    Critical medication: Omission of this medication in some of its indications can lead to serious patient harm of death. Please see continuity of critical medicines guidelines and procedure how to obtain medicines out of hours.
     
    Emtricitabine 200mg, Rilpivirine 25mg and Tenofovir 245mg  (Eviplera®)

    View adult BNF View SPC online View childrens BNF
    Non Formulary
    RedRed

    Critical medication: Omission of this medication in some of its indications can lead to serious patient harm of death. Please see continuity of critical medicines guidelines and procedure how to obtain medicines out of hours.
     
    Lamivudine  (Epivir®)

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    Non Formulary
    Grey

    NHS continuationFor NHS England commissioned services:Unlicensed Prophylactic treatment hepatitis B during immunosuppressive therapy as per NICE CG165HIV in combination with other anti-retroviral drugs - use according to BHIVA Guidelines. Continue in context suitable for shared care between specialist and secondary care via network model. Commissioned by NHS England Area Team.

    Critical medication: Omission of this medication in some of its indications can lead to serious patient harm of death. Please see continuity of critical medicines guidelines and procedure how to obtain medicines out of hours
     

     
    Lamivudine oral solution can be obtained from the following wards:
    Labour ward QEQM
    Labour ward WHH
    Folkstone ward WHH

    Link  Hepatitis B (chronic): Diagnosis and management of chronic hepatitis B in children, young people and adults
     
    Lamivudine  (Zeffix®)

    View adult BNF View SPC online View childrens BNF
    Non Formulary
    Grey
    NHS continuationFor NHS England commissioned services:
  • Unlicensed Prophylactic treatment hepatitis B during immunosuppressive therapy as per NICE CG165
  • HIV in combination with other anti-retroviral drugs - use according to BHIVA Guidelines. Continue in context suitable for shared care between specialist and secondary care via network model. Commissioned by NHS England Area Team.

    Critical medication: Omission of this medication in some of its indications can lead to serious patient harm of death. Please see continuity of critical medicines guidelines and procedure how to obtain medicines out of hours.
  • Link  Guidelines for the management of HIV in pregnancy
    Link  Hepatitis B (chronic): Diagnosis and management of chronic hepatitis B in children, young people and adults
     
    Rilpivirine hydrochloride  (Edurant®)

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    Non Formulary
    Critical medication: Omission of this medication in some of its indications can lead to serious patient harm of death. Please see continuity of critical medicines guidelines and procedure how to obtain medicines out of hours.
     
    Stavudine  (Zerit®)

    View adult BNF View SPC online View childrens BNF
    Non Formulary
    RedRed
    HIV in combination with other anti-retroviral drugs - use according to BHIVA Guidelines. Continue in context suitable for shared care between specialist and secondary care via network model. Commissioned by NHS England Area Team.

    Critical medication: Omission of this medication in some of its indications can lead to serious patient harm of death. Please see continuity of critical medicines guidelines and procedure how to obtain medicines out of hours.
    Link  MHRA safety information on adverse effects April 2011
     
    Tenofovir 245mg, Efavirenz 600mg and Emtricitabine 200mg  (Atripla®)

    View adult BNF View SPC online View childrens BNF
    Non Formulary
    RedRed
    HIV in combination with other anti-retroviral drugs - use according to BHIVA Guidelines. Continue in context suitable for shared care between specialist and secondary care via network model. Commissioned by NHS England Area Team.

    Critical medication: Omission of this medication in some of its indications can lead to serious patient harm of death. Please see continuity of critical medicines guidelines and procedure how to obtain medicines out of hours.
     
    Tenofovir and Emtricitabine  (Truvada®)

    View adult BNF View SPC online View childrens BNF
    Non Formulary
    RedRed
    HIV in combination with other anti-retroviral drugs - use according to BHIVA Guidelines. Continue in context suitable for shared care between specialist and secondary care via network model. Commissioned by NHS England Area Team.

    Critical medication: Omission of this medication in some of its indications can lead to serious patient harm of death. Please see continuity of critical medicines guidelines and procedure how to obtain medicines out of hours.
     
    Zidovudine  (Retrovir®)

    View adult BNF View SPC online View childrens BNF
    Non Formulary
    RedRed

    HIV in combination with other anti-retroviral drugs - use according to BHIVA Guidelines. Continue in context suitable for shared care between specialist and secondary care via network model. Commissioned by NHS England Area Team.

    Critical medication: Omission of this medication in some of its indications can lead to serious patient harm of death. Please see continuity of critical medicines guidelines and procedure how to obtain medicines out of hours
     

     Zidovudine can be obtained from the following wards:
    Labour ward QEQM
    Labour ward WHH
    NICU ward WHH

    Link  Guidelines for the management of HIV in pregnancy
     
    Zidovudine and Lamivudine  (Combivir®)

    View adult BNF View SPC online View childrens BNF
    Non Formulary
    RedRed
    HIV in combination with other anti-retroviral drugs - use according to BHIVA Guidelines. Continue in context suitable for shared care between specialist and secondary care via network model. Commissioned by NHS England Area Team.

    Critical medication: Omission of this medication in some of its indications can lead to serious patient harm of death. Please see continuity of critical medicines guidelines and procedure how to obtain medicines out of hours.
     
      
    Key
    note Notes
    Section Title Section Title (top level)
    Section Title Section Title (sub level)
    First Choice Item First Choice item
    Non Formulary Item Non Formulary section
    Restricted Drug
    Restricted Drug
    Unlicensed Drug
    Unlicensed
    Track Changes
    Display tracking information
    click to search medicines.org.uk
    Link to adult BNF
    click to search medicines.org.uk
    Link to children's BNF
    click to search medicines.org.uk
    Link to SPCs
    Cytotoxic Drug
    Cytotoxic Drug
    CD
    Controlled Drug
    High Cost Medicine
    High Cost Medicine
    Cancer Drugs Fund
    Cancer Drugs Fund
    NHSE
    NHS England
    Homecare
    Homecare
    CCG
    CCG

    Traffic Light Status Information

    Status Description

    Amber

    Requires to be initiated by specialist for repeat GP Prescribing (Purple as per Eclipse East Kent Primary Care Formulary, may be top sliced) If a downloadable EKPG Prescribing Information Sheet exists in the formulary entry for the drug, it, or an URL (shortcut to webpage/document) should be sent to the GP. See also "Hints in how to incorporate documents for medicines information into clinical communications to GPs".  

    Amber 1

    Shared Care (Orange as per Eclipse East Kent Primary Care Formulary). See the Principles of Shared Care Agreements and Shared Care Agreements: Assessment against agreed Principles of Shared Care documents. If a downloadable template document exists in the formulary entry for this drug, it should be sent to the GP (and patient) once patient specific details are incorporated. See "Hints in how to incorporate shared care documents for medicines into clinical communications to GPs".  

    Amber 2

    Shared Care and topsliced (Orange as per Eclipse East Kent Primary Care Formulary) See the Principles of Shared Care Agreements and Shared Care Agreements: Assessment against agreed Principles of Shared Care documents. If a downloadable template document exists in the formulary entry for this drug, it should be sent to the GP (and patient) once patient specific details are incorporated. See "Hints in how to incorporate shared care documents for medicines into clinical communications to GPs".  

    Black

    A decision has been made by either or both the local or national NHS not to routinely commission this preparation for its licensed indications  

    Blue

    No comment on drug in East Kent Primary Care Formulary (Blue as per Eclipse East Kent Primary Care Formulary)  

    Brown

    Exceptional Use Only (Brown as per Eclipse East Kent Primary Care Formulary)   

    Green

    On East Kent Primary Care Formulary (Pink or Green as per Eclipse East Kent Primary Care Formulary)  

    Grey

    Not assessed/Not recommended (As per Eclipse East Kent Primary Care Formulary)  

    Red

    Hospital Only (As per Eclipse East Kent Primary Care Formulary)  

    RedRed

    Known to be commissioned for local NHS patients but only available to them from another provider than EKHUFT  

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